The First Presbyterian Church Sanctuary, sits in the middle of the block amid the church cemetery. The building cornerstone was laid in 1809. The transepts were added in 1859 and in 1924 the church study and choir room were added to the rear of the building.

From the front the original eliptical design and gallery are still evident.

The most recent renovations were completed in 2002 and included repainting and replastering the interior. Electric chandeliers were installed.

At 209 Union Street, in front of the sanctuary, is Mekeel Hall. Originally constructed in 1843 it was enlarged in 1857 and 1883. This building, known as the Chapel for many years, contains a large fellowship hall, meeting and paryer rooms, the church library and a kitchen.

To the east of Mekeel Hall, across the church parking lot, is a brownstone which was the former home of Edward Ellis. Acquired in 1949 to provide space to expand the Sunday School, the debt was cleared by John T. Turnbull as a memorial to his sisters. This building houses the children's ministries of First Presbyterian Church; nurseries and Sunday school classrooms through sixth grade.

One block west, at 115 Union Street, is Goodrich House. Originally constructed in the late eighteenth century for Schenectady Academy, it subsequesntly served as the Schenectady City Hall before being converted to a private dwelling. The last resident, James A. Goodrich, left the house to First Presbyterian Church in 1950 and the church offices were moved there in 1955.